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This Opinion article outlines the relative paucity and emphasizes the need to enhance our knowledge of how subsets of natural killer T (NKT) cells mediate immune mechanisms of elimination of microbial pathogens at sites of inflammation or infection. To date, most studies of how NKT cell subsets migrate upon antigen stimulation have focused on NKT cell activation in the spleen, lymph nodes (LN) and liver (1). Thus, there currently exists an unmet need to determine the patterns of recirculation and tissue migration of NKT cell subsets and interacting antigen-presenting cells (APCs) that occur at relevant mucosal surfaces in several other organs, including the lung, intestine, and colon. This article proposes and highlights the benefit of intravital cellular imaging in vivo of type I and type II NKT cell subsets as an important methodology that may enable the visualization of NKT–APC cellular interactions at mucosal surfaces and enhance the application of this methodology to clinical therapy of antimicrobial immunity.

Imaging of NKT Cell Recirculation and Tissue Migration during Antimicrobial Immunity