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involveswidelydistributedsignals in response to the given environmental input, while bothsystemsmustinteracttoobtaintheirnormalfunctionality(2).Fur-thermore, dysregulation of physiological interactions between thetwosystemscanleadtoseverepregnancy-relateddisordersorcom-plications,such as fetal loss,preterm labor,preeclampsia (PE),andpoor fetal development (3). On the other hand, by amelioratingautoimmuneconditionssuchasmultiplesclerosisandrheumatoidarthritis, while other conditions such as systemic lupus are dete-riorated, pregnancy as a condition may provide a unique insightinto novel immunomodulatory strategies (4,5).The scientic focus on reproductive–immune research hashistorically provided substantial understanding of the inter-face between these two physiological systems. With such recentprogress in the eld, we felt that it is valuable and well-timed toreviewthebroadvarietyof therelevantphysiologicandpathologicaspects – from menstruation to fertilization and implantation,and from placentation and pregnancy

frontiers in immunology

Reproductive Immunology Research: A Tight Interaction between Diverse Scientific and Clinical Disciplines Including Immunology, Obstetrics, Hematology, and Endocrinology