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Attempts to immortalize effector T cells by fusion of normal T cells with T cell lymphomas have been extensively made after the successful establishment of the B cell hybridoma that made it possible to infinitely produce monoclonal antibodies (1, 2). However, T cell hybridomas, which were mostly produced by using the T cell lymphoma line, BW5147, have contributed to T cell biology with limited success, because immortalizing effector T cells by cell fusion dose not necessarily result in immortalizing the bona fide effector functions of parental T cells. Meanwhile, T cells have been becoming recognized as consisting of more diverse populations than previously anticipated (3–6). Furthermore, a new class of lymphocytes termed innate lymphoid cells has been identified; they lack rearranged antigen receptors and are involved not only in immunity but also in inflammation and in tissue remodeling and repair (6–9). Thus, in order to gain a better understanding of the functions of various lymphocytes and their roles in tissue microenvironment, it is desirable to produce functional hybridomas that preserve the effector functions of the parental lymphocytes faithfully. We briefly review phenotypic changes in T cell hybrids from the point of view of somatic cell genetics and describe the concepts and principles behind devising an improved method for immortalizing various lymphocyte functions.

Phenotypic Changes in Growth-Arrested T Cell Hybrids: A Possible Avenue to Produce Functional T Cell Hybridoma