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Autoinflammatory disorders (AIDs) are a group of inherited diseases of innate immunity, characterized by seemingly unprovoked inflammation recurring with variable rhythmicity and involving skin, serosal membranes, synovial membranes, and gastrointestinal tube, with reactive amyloidosis as a potential severe long-term complication (Touitou and Kone-Paut, 2008). They can be categorized in hereditary monogenic disorders and multi-factorial polygenic disorders, encompassing an expanding number of conditions, as the well-known periodic fever, aphthosis, pharyngitis, and adenitis (PFAPA) syndrome (Masters et al., 2009).

Caution Should be Used in the Recognition of Adult-Onset Autoinflammatory Disorders: Facts or Fiction?