English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objectives:  General population studies have shown associations between copy number variation (CNV) of the  LPA  gene Kringle-IV type-2 (KIV-2) coding region, single-nucleotide polymorphism (SNP) rs6415084 in  LPA  and coronary heart disease (CHD). Because risk factors for HIV-infected patients may differ from the general population, we aimed to assess whether these potential associations also occur in HIV-infected patients.  Methods:  A unicenter, retrospective, case–control (1:3) study. Eighteen HIV-patients with confirmed diagnosis of acute myocardial infarction (AMI) were adjusted for age, gender, and time since HIV diagnosis to 54 HIV-patients without CHD. After gDNA extraction from frozen blood, both CNV and SNP genotyping were performed using real-time quantitative PCR. All genetic and non-genetic variables for AMI were assessed in a logistic regression analysis.  Results:  Our results did not confirm any association in terms of lipoprotein(a)  LPA  structural genetic variants when comparing KIV-2 CNV ( p  = 0.67) and SNP genotypes ( p  = 0.44) between AMI cases and controls. However, traditional risk factors such as diabetes mellitus, hypertension, and CD4 +  T cell count showed association ( p  < 0.05) with CHD.  Conclusion:  Although significant associations of AMI with diabetes, hypertension and CD4 +  T cell count in HIV-patients were found, this study could not confirm the feasibility neither of KIV-2 CNV nor rs6415084 in  LPA  as genetic markers of CHD in HIV-infected patients.   Highlights :  ● Individuals with HIV infection are at higher risk of coronary heart disease (CHD) than the non-infected population.  ● Our results showed no evidence of  LPA  structural genetic variants associated with CHD in HIV-1-infected patients.  ● Associations were found between diabetes mellitus, arterial hypertension, CD4 +  T cell count, and CHD.  ● The clinical usefulness of these biomarkers to predict CHD in HIV-1-infected population remains unproven.  ● Further studies are needed to assess the contribution of common genetic variations to CHD in HIV-infected individuals.

Association study of lipoprotein(a) genetic markers, traditional risk factors, and coronary heart disease in HIV-1-infected patients