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Background:  Electroacupuncture is a common treatment for chronic atrophic gastritis (CAG) in China. We aimed to determine the effects of electroacupuncture at zusanli (ST36) on intestinal microbiota in CAG rats.   Methods:  In total, 42 SD rats were randomly divided into normal (NC, 10 rats) and model (MG, 32 rats) groups. Rats in the MG group were established as CAG disease models. After that, the rats in the MG group were randomly divided into CAG (10 rats), electroacupuncture (EA, 10 rats), and Vitacoenzyme (Vit, 10 rats) groups. Rats in the NC and CAG groups were subjected to a 30-min/d confinement for 4 weeks. Rats in the EA group were given electroacupuncture at zusanli for 30 min/d for 4 weeks. Rats in the Vit group were given Vitacoenzyme solution 10 ml/(kg d) for 4 weeks. Histopathological changes in the gastric mucosa were observed with hematoxylin and eosin staining, and the gene expression level of p53, Bcl-2, and c-myc was determined using the qPCR method. The 16S rDNA sequencing technique was used to determine structural changes and relative abundance expression of intestinal flora.   Results:  Compared with the NC group, gastric mucosal pathology in the CAG group revealed significant inflammatory infiltration, and the gastric mucosal lesions in the electroacupuncture group were improved remarkably; the expression of p53 and c-myc genes in the CAG group increased ( p  &amp;lt; 0.05), while the expression of Bcl-2 genes decreased ( p  &amp;lt; 0.05) in the EA group, that of p53 and c-myc genes decreased ( p  &amp;lt; 0.05), and that of Bcl-2 genes increased ( p  &amp;lt; 0.05). The abundance of bacteria such as  Lactobacillus ,  Desulfobacterota , and  Bacteroides pectinophilus group  in the CAG group increased ( p  &amp;lt; 0.05), while that of bacteria such as  Gastranaerophilales ,  Romboutsia , and  Blautia  decreased ( p  &amp;lt; 0.05). The relative abundance of  Desulfobacterota  and  Helicobacter  in the EA group decreased ( p  &amp;lt; 0.05), while that of probiotic bacteria such as  Oscillospirales ,  Romboutsia , and Christensenellaceae increased ( p  &amp;lt; 0.05).   Conclusion:  Electroacupuncture at zusanli can promote the repair of pathological damage to the gastric mucosa in rats with CAG, and the mechanism might relate to the reduction in the relative abundance of harmful bacteria, increase in the relative abundance of intestinal probiotics, and regulation of the intestinal microbiota.

Effect of Electroacupuncture at Zusanli (ST36) on Intestinal Microbiota in Rats With Chronic Atrophic Gastritis