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Objective:  This study aimed to investigate the expression and biological functions of  TNK2  and miR-125a-3p in colon cancer.   Materials and methods:  The expression of  TNK2  and miR-125a-3p in colon cancer tissues was analyzed using data deposited on public databases including UALCAN and ONCOMINE. We verified their expression in colon cancer cell lines by RT-qPCR and western blotting. By regulating the expression of  TNK2  and miR-125a-3p in colon cancer cells, their functions and potential mechanisms were explored.   Results:  TNK2  was overexpressed in colon cancer cell lines, and it was found to directly bind to miR-125a-3p, which was downregulated in these cell lines. Their expression affected the proliferation and invasion of colon cancer cells. Additionally, colon cancer patients with lower  TNK2  expression had better prognoses than those with higher  TNK2  expression.   Conclusion:  Our results indicated that  TNK2  and miR-125a-3p play critical roles in colon cancer, and could also serve as biomarkers for the diagnosis and prognosis of this malignant disease.

Significant Gene Biomarker Tyrosine Kinase Non-receptor 2 Mediated Cell Proliferation and Invasion in Colon Cancer