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There is an urgent and well-recognized need to extend genetic studies todiverse populations, but several obstacles continue to be prohibitive,including (but not limited to) the difficulty of recruiting individuals fromdiverse populations in large numbers and the lack of representation inavailable genomic references. These obstacles notwithstanding, studyingmultiple diverse populations would provide informative, population-specificinsights. Using Native Hawaiians as an example of an understudied populationwith a unique evolutionary history, I will argue that by developing key genomicresources and integrating evolutionary thinking into genetic epidemiology, wewill have the opportunity to efficiently advance our knowledge of the geneticrisk factors, ameliorate health disparity, and improve healthcare in thisunderserved population.

frontiers in genetics

The opportunities and challenges of integrating population histories  into genetic studies of diverse populations: a motivating example from Native  Hawaiians