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The involvement of genes and miRNAs in the development of atherosclerosis is a challenging problem discussed in recent publications. It is necessary to establish which miRNAs affect the expression of candidate genes. We used known candidate atherosclerosis genes to predict associations. The quantitative characteristics of interactions of miRNAs with mRNA candidate genes were determined using the program, which identifies the localization of miRNA binding sites in mRNA, the free energy interaction of miRNA with mRNA. In mRNAs of  GAS6  and  NFE2L2  candidate genes, binding sites of 21 miRNAs and of 15 miRNAs, respectively, were identified. In  IRS2  mRNA binding sites of 25 miRNAs were located in a cluster of 41 nt. In  ADRB3, CD36, FASLG, FLT1, PLA2G7 , and  PPARGC1A  mRNAs, clusters of miR-466, ID00436.3p-miR, and ID01030.3p-miR BS were identified. The organization of overlapping miRNA binding sites in clusters led to their compaction and caused competition among the miRNAs. The binding of 53 miRNAs to the mRNAs of 14 candidate genes with free energy interactions greater than −130 kJ/mole was determined. The miR-619-5p was fully complementary to  ADAM17  and  CD36  mRNAs, ID01593.5p-miR to  ANGPTL4  mRNA, ID01935.5p-miR to  NFE2L2 , and miR-5096 to  IL18  mRNA. Associations of miRNAs and candidate atherosclerosis genes are proposed for the early diagnosis of this disease.

In silico Prediction of miRNA Interactions With Candidate Atherosclerosis Gene mRNAs