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Objectives  To determine the effects of genetic polymorphisms of ABCB1 (MDR1), CYP2A6, CYP2B6 on smoking status, and clinical outcomes of smoking cessation therapies in a Turkish population.    Methods  130 smokers and 130 non-smokers were recruited. Individuals who never smoked were described as non-smokers. 130 smokers were treated with nicotine replacement therapy (NRT) ( n  = 40), bupropion ( n  = 47), bupropion + NRT ( n  = 15), and varenicline ( n  = 28). Smokers were checked by phone after 12 weeks of treatment whether they were able to quit smoking or not. Genotyping and phenotyping were performed.    Results  Cessation rates were as follows; 20.0% for NRT, 29.8% for bupropion, 40.0% for bupropion + NRT, 57.1% for varenicline ( p  = 0.013). The frequency of ABCB1  1236TT-2677TT-3435TT  haplotype was significantly higher in non-smokers as compared to smokers (21.5% vs. 10.8, respectively;  p  = 0.018). Neither smoking status nor smoking cessation rates were associated with genetic variants of CYP2A6 ( p  = 0.652,  p  = 0.328, respectively), or variants of CYP2B6 ( p  = 0.514,  p  = 0.779, respectively).    Conclusion  Genetic variants of the drug transporter ABCB1 and the  1236TT-2677TT-3435TT  haplotype was significantly associated with non-smoking status. Neither ABCB1 nor CYP2A6, CYP2B6 genetic variants were associated with smoking cessation rates at the 12th week of drug treatment.

frontiers in genetics

Effects of Genetic Polymorphisms of Drug Transporter ABCB1 (MDR1) and Cytochrome P450 Enzymes CYP2A6, CYP2B6 on Nicotine Addiction and Smoking Cessation