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MiR-430  is considered an important regulator during embryonic development, but genetic loss-of-function study is still lacking. Here we demonstrated that genetic deletion of the  miR-430  cluster resulted in developmental defects in cell movement, germ layer specification, axis patterning and organ progenitor formation in zebrafish. Transcriptome analysis indicated that the maternally provided transcripts were not properly degraded whereas the zygotic genome expressed genes were not fully activated in the  miR-430  mutants. We further found that a reciprocal regulatory loop exists between  miR-430  and maternally provided transcripts: the maternally provided transcripts ( Nanog ,  Dicer1 ,  Dgcr8 , and  AGOs ) are required for  miR-430  biogenesis and function, whereas  miR-430  is required for the clearance of these maternally provided transcripts. These data provide the first genetic evidence that  miR-430  is required for maternal-zygotic transition and subsequent establishment of embryonic body plan.

Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan