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Objective:  Essential tremor (ET) is a common movement disorder that has a high heritability. A number of genetic studies have associated different genes and loci with ET, but few have investigated the biology of any of these genes.  STK32B  was significantly associated with ET in a large genome-wide association study (GWAS) and was found to be overexpressed in ET cerebellar tissue. The objective of this study is to determine the effects of overexpressed  STK32B  in cerebellar DAOY cells.   Methods:  Here, we overexpressed  STK32B  RNA in human cerebellar DAOY cells and used an RNA-Seq approach to identify differentially expressed genes (DEGs) by comparing the transcriptome profile of these cells to one of the control DAOY cells.   Results:  Pathway and gene ontology enrichment identified axon guidance, olfactory signaling, and calcium-voltage channels as significant. Additionally, we show that overexpressing  STK32B  affects transcript levels of previously implicated ET genes such as  FUS .   Conclusion:  Our results investigate the effects of overexpressed  STK32B  and suggest that it may be involved in relevant ET pathways and genes.

Transcriptomic Changes Resulting From STK32B Overexpression Identify Pathways Potentially Relevant to Essential Tremor