English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

For datasets of gastric cancer collected by TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus) repositories, we applied a bioinformatics approach to obtain expression data for the  ISLR  (immunoglobulin superfamily containing leucine-rich repeat) gene, which is highly expressed in gastric cancer tissues and closely associated with clinical prognosis. Although we did not observe an overall association of  ISLR  mutation, high expression or copy number variation with survival, hypomethylation of four methylated sites (assessed by the probes cg05195566, cg17258195, cg09664357, and cg07297039) of  ISLR  was negatively correlated with high expression levels of  ISLR  and was associated with poor clinical prognosis. In addition, we detected a correlation between  ISLR  expression and the infiltration levels of several immune cells, especially CD8 +  T cells, macrophages and dendritic cells. We also identified a series of genes that were positively and negatively correlated with  ISLR  expression based on the TCGA-STAD, GSE13861, and GSE29272 datasets. Principal component analysis and random forest analysis were employed to further screen for six hub genes, including  ISLR ,  COL1A2 ,  CDH11 ,  SPARC ,  COL3A1 , and  COL1A1 , which exhibited a good ability to differentiate between tumor and normal samples. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and gene set enrichment analysis data also suggested a potential relationship between  ISLR  gene expression and epithelial-mesenchymal transition (EMT).  ISLR  expression was negatively correlated with sensitivity to PX-12 and NSC632839. Taken together, these results show that the  ISLR  gene is involved in gastric carcinogenesis, and the underlying molecular mechanisms may include DNA methylation, EMT, and immune cell infiltration.

An Analysis Regarding the Association Between the ISLR Gene and Gastric Carcinogenesis