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Endometrial cancer (EC) is one of the most common gynecologic malignancies. Emerging studies had demonstrated the mutations in genes could serve as diagnostic or prognostic markers for human cancers. In this study, we screened mutated genes in EC and found that the mutations in  KIAA1109, CACNA1C, BSN, AKAP13, CELSR2,  and  HELZ2  were correlated to the overall survival time in patients with EC. Bioinformatics analysis showed  KIAA1109  was involved in regulating NIK/NF-kappaB signaling,  CACNA1C  was found to regulate cell migration and proliferation,  BSN  was found to regulate Wnt signaling pathway,  CELSR2  was involved in regulating cell–cell adhesion, nuclear import, and protein folding,  HELZ2  was found to regulate multiple immune related biological processes, and  AKAP13  was involved in regulating translation, mRNA nonsense-mediated decay, rRNA processing, translational initiation, and mRNA splicing  via  spliceosome. The findings provided a novel therapeutic strategy in patients with EC.

Mutations in KIAA1109, CACNA1C, BSN, AKAP13, CELSR2, and HELZ2 Are Associated With the Prognosis in Endometrial Cancer