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Following our recent Review article (Gonzalez-Recio et al., 2015), we received correspondence by Steele (2016). We thank Dr. Steele for his comments, which provide a thorough review of his work on human immunology, which has persuaded him that “hard types of soma-to-germline transfer are ongoing at very high frequency in human immune system germlines.” His and other researchersu0027 studies on reverse transcriptase (RT) based feedback mechanisms showed that RNA could be retrotranscripted to DNA, and it can be inserted into the mammalian germline, and therefore be transferred to the progeny.

Response: Commentary: Past, present and future of epigenetics applied to livestock breeding