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Genomic imprinting, the preferential expression of maternal or paternal alleles of imprinted genes, is often maintained through expression of imprinted long non-coding (lnc) “antisense” RNAs. These may overlap imprinted transcripts, and are expressed from the opposite allele. Previously we have described brain region-specific imprinted expression of the  Dio3  gene in rat, which is preferentially modified by fetal ethanol exposure. The  Dio3os  (opposite strand) transcript is transcribed in opposite orientation to  Dio3  in mouse and human, partially overlaps the  Dio3  promoter, and mirrors total  Dio3  developmental expression levels. Here, we present that the rat  Dio3os  transcript(s) exhibits brain region-specific imprinted expression patterns similar to those of  Dio3 . Rat  Dio3os  transcript expression is also similarly modified by fetal ethanol exposure. Uniquely, both  Dio3  and  Dio3os  expression occur on the same, rather than opposite, alleles, as determined by strand-specific RT-PCR. Future studies will require direct manipulation of the  Dio3os  transcript to determine whether the novel paralleling of total and allele-specific expression patterns of this sense/antisense imprinted gene pair reflects an as-yet undefined regulatory mechanism for lncRNA mediated tissue-specific imprinted expression, or rather is a consequence of a more straightforward, but previously undescribed transcriptional coregulation process.

Imprinting and expression of Dio3os mirrors Dio3 in rat