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One of the neglected issues in this article is the role of genetic variation with age-independent genetic effects. Genetic variation affecting aging and other life-history characters can, in theory, be maintained by mutation-selection balance for genes that are age-specific in expression, where the expectation is a higher additive genetic variance of fitness components at more advanced ages. However, this mechanism – accumulation of mutations – though leading to the maintenance of genetic variation, does not involve a consistent performance across ages, and thus does not produce a plateau late in life characterized by the type of positive correlations assumed by lifelong heterogeneity theories. But in any case, both age-independent and age-dependent mechanisms will play a role in defining the timing and state at which aging stops.

A Question Never Comes Alone: Comments on ‘What is Aging?’