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Gestational diabetes mellitus (GDM) is a disease that changes the function of microvascular of placenta. MicroRNA (miRNA) expression in placenta may contribute to the pathogenesis of GDM. Here, we evaluate the role and function of  miR-29b  in the development of GDM. This study discovered that  miR-29b  expression was lower in placentas derived from patients with GDM than that in control placentas.  MiR-29b  over-expression inhibited cell growth and migration, and  miR-29b  knockdown promoted cell migration. Then we predicted and confirmed that  HIF3A  was a direct target of  miR-29b  with two specific binding sites at the recognition sequences of  miR-29b  in 3′-UTR of  HIF3A  mRNA, which was negatively correlated with  miR-29b  expression level. The up-regulation of  HIF3A  partially antagonized the inhibitory effect of  miR-29b  over-expression on cell growth and migration. The enhancement of cell migration induced by  miR-29b  knockdown was attenuated by down-regulating  HIF3A . These results imply that down-regulation of  miR-29b  may be related with the development of GDM partially via increasing the expression of  HIF3A , which may provide a new insight for the mechanism of GDM.

frontiers in endocrinology

The miRNA-29b Is Downregulated in Placenta During Gestational Diabetes Mellitus and May Alter Placenta Development by Regulating Trophoblast Migration and Invasion Through a HIF3A-Dependent Mechanism