English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Neuropeptide FF (NPFF) is a family member of RF-amide peptides, which are suggested to be involved in the control of vertebrate feeding behavior. However, little is known about the effect of the NPFF peptide on feeding-related processes in basal vertebrates. In this study, four full-length cDNAs,  npff ,  npffr1, npffr2-1 , and  npffr2-2 , were cloned from spotted sea bass and characterized. The conserved NPFF peptide is biologically active because it functionally interacts with different receptors expressed in cultured eukaryotic cells to enhance CRE promoter activity. Tissue distribution analysis showed that the highest  npff  mRNA expression occurred in the telencephalon, hypothalamus, medulla, gonad and muscle, but the  npffr s mRNAs were mainly distributed within the central nervous system (CNS).  In situ  hybridization (ISH) detected  npff -expressing cells in several specific regions ranging across the telencephalon and midbrain to the hypothalamus. Incubation of the spotted sea bass conserved NPFF peptide significantly increased the expression of  orexin  ( orx ) and  neuropeptide Y  ( npy ) mRNA and decreased the expression of  leptin  ( lep ),  somatostatin  ( ss ), and  cholecystokinin  ( cck ) mRNA in brain cells. Similarly, the conserved NPFF peptide also heightened the expression of  gastrin  ( gas ),  ghrelin  ( ghrl ), and  motilin  ( mtl ) mRNA and significantly reduced the expression of  cck  mRNA in the intestine and stomach. Taken together, these data suggest that the NPFF peptide may play a stimulating role in regulating feeding-related processes in spotted sea bass.

Evidence for the Direct Effect of the NPFF Peptide on the Expression of Feeding-Related Factors in Spotted Sea Bass (Lateolabrax maculatus)