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Background  Although  solute carrier family 30 (zinc transporter) member 8 (SLC30A8)  gene 807C/T polymorphism is associated with an increased risk of type 2 diabetes mellitus (T2DM) risk, there remains some inconsistency between individual studies.    Objective  The aim of the study is to explore the relationship between  SLC30A8  gene 807C/T polymorphism and T2DM in the Chinese population.    Methods  The current meta-analysis compiles and analyzes the data of 6,942 participants from 10 independent studies. Either a fixed or random-effects model was adopted to evaluate the pooled odds ratio (ORs) and the corresponding 95% confidence interval (95% CI).    Results  A significant association between  SLC30A8  gene 807C/T polymorphism and T2DM was found in the Chinese population under allelic (OR: 0.85, 95% CI: 0.80–0.91,  P  = 7.42 × 10 −7 ), recessive (OR: 0.52, 95% CI: 0.38–0.72,  P  = 8.49 × 10 −5 ), dominant (OR: 2.40, 95% CI: 1.68–3.41,  P  = 1.30 × 10 −6 ), homozygous (OR: 0.52, 95% CI: 0.40–0.67,  P  = 2.90 × 10 −7 ), heterozygous (OR: 0.79, 95% CI: 0.71–0.88,  P  = 1.63 × 10 −5 ), and additive genetic models (OR: 0.73, 95% CI: 0.64–0.83,  P  = 7.05 × 10 −7 ).    Conclusion   SLC30A8  gene 807C/T polymorphism was significantly associated with an increased T2DM risk in the Chinese population. Therefore, individuals of Chinese descent with the C allele of  SLC30A8  gene 807C/T polymorphism may be more susceptible to developing T2DM, while individuals with the T allele may be protected against T2DM.

frontiers in endocrinology

Solute Carrier Family 30 Member 8 Gene 807C/T Polymorphism and Type 2 Diabetes Mellitus in the Chinese Population: A Meta-Analysis Including 6,942 Subjects