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Background  Cardiac troponin-T ( TNNT2 ) is exclusively present in cardiac muscle. Measurement of  TNNT2  is used for diagnosing acute coronary syndrome. However, its expression may not be limited in myocardium. This study aimed at evaluating the expression of  TNNT2  in neoplastic tissues.    Methods and Results  We used paraffin-embedded blocks of 68 patients with lung cancer (age, 68 ± 11 years old; early-stage, 33; advance-stage, 35) at Miyazaki University Hospital, Japan between January 1, 2017, and March 31, 2019. We stained the slide sections with primary monoclonal antibody against  TNNT2  protein, and assessed the frequency of positive staining, and its association with pathological severity. In addition, we examined whether  TNNT2  gene is detected in lung cancer tissues of four patients using reverse transcription-polymerase chain reaction. Immunoreactivity for  TNNT2  protein was present in the cytoplasm and nucleus of lung cancer cells. The frequency was 37% (25 of 68) in all patients and was irrespective of histologic type (six of 13, squamous cell carcinoma; 18 of 50, adenocarcinoma; 0 of 4, neuroendocrine cell carcinoma; 1 of 1, large cell carcinoma). The prevalence increased with pathological staging [9% (3 of 33) at early-stage (Stage 0–I); 63% (22 of 35) at advance-stage (Stage II–IV and recurrence)]. In addition, frequency of positive staining for  TNNT2  increased with pleural (χ 2  = 5.877,  P  = 0.015) and vascular (χ 2  = 2.449,  P  = 0.118) invasions but decreased with lymphatic invasion (χ 2  = 3.288,  P  = 0.070) in specimens performed surgical resection. Furthermore,  TNNT2  mRNA was detected in the resected squamous cell carcinoma and adenocarcinoma tissues.    Conclusions  Our data suggest the aberrant expression of  TNNT2  in lung cancer and its prevalence increases with pathological severity.

Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity