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Objective:  Research has shown a possible relationship between the E670G polymorphism of the  proprotein convertase subtilisin/kexin type 9  ( PCSK9 ) gene and an increased risk of coronary artery disease (CAD). However, there is no clear consensus on the subject because of conflicting results in the literature. The current meta-analysis was performed to better elucidate the potential relationship between the  PCSK9  gene E670G polymorphism and CAD.   Methods:  There were 5,484 subjects from 13 individual studies who were included in the current meta-analysis. The fixed- or random-effects models were used to evaluate the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).   Results:  The current meta-analysis found a significant association between  PCSK9  gene E670G polymorphism and CAD under allelic (OR = 1.79, 95% CI = 1.42–2.27,  P  = 1.00 × 10 −6 ), dominant (OR = 2.16, 95% CI = 1.61–2.89,  P  = 2.22 × 10 −7 ), heterozygous (OR = 2.02, 95% CI = 1.55–2.64,  P  = 2.47 × 10 −7 ), and additive genetic models (OR = 1.92, 95% CI = 1.49–2.49,  P  = 6.70 × 10 −7 ).   Conclusions:   PCSK9  gene E670G polymorphism was associated with an elevated risk of CAD, especially in the Chinese population. More specifically, carriers of the G allele carriers of the  PCSK9  gene may be predisposed to developing CAD.

PCSK9 Gene E670G Polymorphism and Coronary Artery Disease: An Updated Meta-Analysis of 5,484 Subjects