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Leucocyte- and platelet rich fibrin (L-PRF) is an autologous biomaterial used in regenerative procedures. It has an antimicrobial activity against  P. gingivalis  although the mechanism is not fully understood. It was hypothesized that L-PRF exudate releases hydrogen peroxide and antimicrobial peptides that inhibit  P. gingivalis  growth. Agar plate and planktonic culture experiments showed that the antimicrobial effect of L-PRF exudate against  P. gingivalis  was supressed by peroxidase or pepsin exposure. In developing multi-species biofilms, the antimicrobial effect of L-PRF exudate was blocked only by peroxidase, increasing  P. gingivalis  growth with 1.3 log genome equivalents. However, no effect was shown on other bacteria. Pre-formed multi-species biofilm trials showed no antimicrobial effect of L-PRF exudate against  P. gingivalis  or other species. Our findings showed that L-PRF exudate may release peroxide and peptides, which may be responsible for its antimicrobial effect against  P. gingivalis . In addition, L-PRF exudate had an antimicrobial effect against  P. gingivalis  in an  in vitro  developing multi-species biofilm.

frontiers in cellular and infection microbiology

Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against Planktonic Porphyromonas gingivalis and Within Multi-Species Biofilm: A Pilot Study