English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Fungal infections are increasing in prevalence worldwide. The paucity of available antifungal drug classes, combined with the increased occurrence of multidrug resistance in fungi, has led to new clinical challenges in the treatment of fungal infections.  Candida auris  is a recently emerged multidrug resistant human fungal pathogen that has become a worldwide public health threat.  C. auris  clinical isolates are often resistant to one or more antifungal drug classes, and thus, there is a high unmet medical need for the development of new therapeutic strategies effective against  C. auris . Additionally,  C. auris  possesses several virulence traits, including the ability to form biofilms, further contributing to its drug resistance, and complicating the treatment of  C. auris  infections. Here we assessed red, green, and blue visible lights alone and in combination with photosensitizing compounds for their efficacies against  C. auris  biofilms. We found that (1) blue light inhibited and disrupted  C. auris  biofilms on its own and that the addition of photosensitizing compounds improved its antibiofilm potential; (2) red light inhibited and disrupted  C. auris  biofilms, but only in combination with photosensitizing compounds; and (3) green light inhibited  C. auris  biofilms in combination with photosensitizing compounds, but had no effects on disrupting  C. auris  biofilms. Taken together, our findings suggest that photodynamic therapy could be an effective non-drug therapeutic strategy against multidrug resistant  C. auris  biofilm infections.

Photodynamic Therapy Is Effective Against Candida auris Biofilms