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This study explored the association between oral microbes and head and neck cancer (HNC) as well as symptoms related to patients with HNC before surgical treatment. Fifty-six patients with HNC and 64 matched healthy controls were recruited from West China hospital in Southwest China. The demographic, clinical, and symptom data were collected. Salivary samples were collected to determine the microbial characteristics using 16S rRNA gene sequencing. Patients with HNC presented increased  Capnocytophaga  abundances. The oral microbial markers as  Capnocytophaga  (area under the curve=0.81) achieved a high classification power between the HNC patients and healthy controls. Moreover, using  Capnocytophaga  in conjunction with symptom of voice/speech difficulty achieved an overall predicting accuracy of 92.5% comparing with using  Capnocytophaga  alone (79.2% accuracy) in distinguishing the HNC patients from healthy controls. Salivary microbial profiles and HNC symptoms may be potential biomarkers for HNC screening.

Study on the Salivary Microbial Alteration of Men With Head and Neck Cancer and Its Relationship With Symptoms in Southwest China