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Aeromonas veronii  is a Gram-negative species ubiquitous in different aquatic environments and capable of causing a variety of diseases to a broad host range.  Aeromonas  species have the capability to carry and acquire antimicrobial resistance (AMR) elements, and currently multi-drug resistant (MDR)  Aeromonas  isolates are commonly found across the world.  A. veronii  strain MS-17-88 is a MDR strain isolated from catfish in the southeastern United States. The present study was undertaken to uncover the mechanism of resistance in MDR  A. veronii  strain MS-17-88 through the detection of genomic features. To achieve this, genomic DNA was extracted, sequenced, and assembled. The  A. veronii  strain MS-17-88 genome comprised 5,178,226-bp with 58.6% G+C, and it encoded several AMR elements, including  imiS, ampS, mcr-7.1, mcr-3, catB2, catB7, catB1, floR, vat(F), tet(34), tet(35), tet(E), dfrA3 , and  tetR . The phylogeny and resistance profile of a large collection of  A. veronii  strains, including MS-17-88, were evaluated. Phylogenetic analysis showed a close relationship between MS-17-88 and strain Ae5 isolated from fish in China and ARB3 strain isolated from pond water in Japan, indicating a common ancestor of these strains. Analysis of phage elements revealed 58 intact, 63 incomplete, and 15 questionable phage elements among the 53  A. veronii  genomes. The average phage element number is 2.56 per genome, and strain MS-17-88 is one of two strains having the maximum number of identified prophage elements (6 elements each). The profile of resistance against various antibiotics across the 53  A. veronii  genomes revealed the presence of  tet(34), mcr-7.1, mcr-3 , and  dfrA3  in all genomes (100%). By comparison,  sul1  and  sul2  were detected in 7.5% and 1.8% of  A. veronii  genomes. Nearly 77% of strains carried  tet(E) , and 7.5% of strains carried  floR . This result suggested a low abundance and prevalence of sulfonamide and florfenicol resistance genes compared with tetracycline resistance among  A. veronii  strains. Overall, the present study provides insights into the resistance patterns among 53  A. veronii  genomes, which can inform therapeutic options for fish affected by  A. veronii .

Identification of Antimicrobial Resistance Determinants in Aeromonas veronii Strain MS-17-88 Recovered From Channel Catfish (Ictalurus punctatus)