English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Enolase is an evolutionarily conserved enzyme involved in the processes of glycolysis and gluconeogenesis.  Mycoplasma hyopneumoniae  belongs to  Mycoplasma , whose species are wall-less and among the smallest self-replicating bacteria, and is an important colonizing respiratory pathogen in the pig industry worldwide.  Mycoplasma hyopneumoniae  enolase ( Mhp  Eno) expression is significantly increased after infection and was previously found to be a virulence factor candidate. Our studies show that  Mhp  Eno is a cell surface-localized protein that can adhere to swine tracheal epithelial cells (STECs). Adhesion to STECs can be specifically inhibited by an  Mhp  Eno antibody.  Mhp  Eno can recognize and interact with plasminogen with high affinity. Here, the first crystal structure of the mycoplasmal enolase from  Mycoplasma hyopneumoniae  was determined. The structure showed unique features of  Mhp  Eno in the S3/H1, H6/S6, H7/H8, and H13 regions. All of these regions were longer than those of other enolases and were exposed on the  Mhp  Eno surface, making them accessible to host molecules. These results show that  Mhp  Eno has specific structural characteristics and acts as a multifunctional adhesin on the  Mycoplasma hyopneumoniae  cell surface.

Featured Species-Specific Loops Are Found in the Crystal Structure of Mhp Eno, a Cell Surface Adhesin From Mycoplasma hyopneumoniae