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Objectives:  The potential linkage between  Cryptosporidium  spp. infection and colorectal human cancer was suggested by limited reports showing higher prevalence of  C. parvum  and  C. hominis  in patients with colon cancer. Here we conducted research concerning presence of  Cryptosporidium  spp. in malignant tissue collected from patients with colorectal cancer.   Methods:  Cancerous colon tissue samples collected from 145 non-HIV infected patients with colorectal cancer were screened for  Cryptosporidium  spp. by immunofluorescence antibody test and genus-specific nested polymerase chain reaction followed by sequencing.   Results:  Screened pathogen was found in cancerous tissue originating from immunocompetent man with colon adenocarcinoma. Genotyping revealed presence of  Cryptosporidium meleagridis . The presence of  Cryptosporidium  life cycle stages (oocysts and endogenous stages) in colon carcinoma tissue was confirmed by genus-specific FITC-labeling.   Conclusions:  Herein, we report on a  C. meleagridis  infection of a colon adenocarcinoma in an immunocompetent patient. This is the first report of  C. meleagridis  infection in the human colon and first evidence of active development of this species in cancer tissue.

The First Evidence of Cryptosporidium meleagridis Infection in a Colon Adenocarcinoma From an Immunocompetent Patient