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Historically, Campylobacteriosis has been considered to be zoonotic; the  Campylobacter  species that cause human acute intestinal disease such as  Campylobacter jejuni  and  Campylobacter coli  originate from animals. Over the past decade, studies on human hosted  Campylobacter  species strongly suggest that  Campylobacter concisus  plays a role in the development of inflammatory bowel disease (IBD).  C. concisus  primarily colonizes the human oral cavity and some strains can be translocated to the intestinal tract. Genome analysis of  C. concisus  strains isolated from saliva samples has identified a bacterial marker that is associated with active Crohn's disease (one major form of IBD). In addition to  C. concisus , humans are also colonized by a number of other  Campylobacter  species, most of which are in the oral cavity. Here we review the most recent advancements on  C. concisus  and other human hosted  Campylobacter  species including their clinical relevance, transmission, virulence factors, disease associated genes, interactions with the human immune system and pathogenic mechanisms.

The Clinical Importance of Campylobacter concisus and Other Human Hosted Campylobacter Species