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Shigella  is the major cause of bacillary dysentery world-wide. It is divided into four species, named  S. flexneri, S. sonnei, S. dysenteriae , and  S. boydii , which are distinct genomically and in their ability to cause disease. Shigellosis, the clinical presentation of  Shigella  infection, is characterized by watery diarrhea, abdominal cramps, and fever.  Shigella 's ability to cause disease has been attributed to virulence factors, which are encoded on chromosomal pathogenicity islands and the virulence plasmid. However, information on these virulence factors is not often brought together to create a detailed picture of infection, and how this translates into shigellosis symptoms. Firstly,  Shigella  secretes virulence factors that induce severe inflammation and mediate enterotoxic effects on the colon, producing the classic watery diarrhea seen early in infection. Secondly,  Shigella  injects virulence effectors into epithelial cells via its Type III Secretion System to subvert the host cell structure and function. This allows invasion of epithelial cells, establishing a replicative niche, and causes erratic destruction of the colonic epithelium. Thirdly,  Shigella  produces effectors to down-regulate inflammation and the innate immune response. This promotes infection and limits the adaptive immune response, causing the host to remain partially susceptible to re-infection. Combinations of these virulence factors may contribute to the different symptoms and infection capabilities of the diverse  Shigella  species, in addition to distinct transmission patterns. Further investigation of the dominant species causing disease, using whole-genome sequencing and genotyping, will allow comparison and identification of crucial virulence factors and may contribute to the production of a pan- Shigella  vaccine.

How Do the Virulence Factors of Shigella Work Together to Cause Disease?