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Trypanosoma vivax  is the most prevalent trypanosome species in African cattle. It is thought to be transmitted by tsetse flies after cyclical development restricted to the vector mouthparts. Here, we investigated the kinetics of  T. vivax  development in  Glossina morsitans morsitans  by serial dissections over 1 week to reveal differentiation and proliferation stages. After 3 days, stable numbers of attached epimastigotes were seen proliferating by symmetric division in the cibarium and proboscis, consistent with colonization and maintenance of a parasite population for the remaining lifespan of the tsetse fly. Strikingly, some asymmetrically dividing cells were also observed in proportions compatible with a continuous production of pre- metacyclic trypomastigotes. The involvement of this asymmetric division in  T. vivax  metacyclogenesis is discussed and compared to other trypanosomatids.

The Cyclical Development of Trypanosoma vivax in the Tsetse Fly Involves an Asymmetric Division