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Here we report the draft genomes and annotation of four  N -acyl homoserine lactone (AHL)-producing members from the family  Sphingomonadaceae . Comparative genomic analyses of 62  Sphingomonadaceae  genomes were performed to gain insights into the distribution of the canonical  luxI/R -type quorum sensing (QS) network within this family. Forty genomes contained at least one  luxR  homolog while the genome of  Sphingobium yanoikuyae  B1 contained seven Open Reading Frames (ORFs) that have significant homology to that of  luxR . Thirty-three genomes contained at least one  luxI  homolog while the genomes of  Sphingobium  sp. SYK6,  Sphingobium japonicum , and  Sphingobium lactosutens  contained four  luxI . Using phylogenetic analysis, the sphingomonad LuxR homologs formed five distinct clades with two minor clades located near the plant associated bacteria (PAB) LuxR solo clade. This work for the first time shows that 13  Sphingobium  and one  Sphingomonas  genome(s) contain three convergently oriented genes composed of two tandem  luxR  genes proximal to one  luxI  ( luxR-luxR-luxI ). Interestingly,  luxI  solos were identified in two  Sphingobium  species and may represent species that contribute to AHL-based QS system by contributing AHL molecules but are unable to perceive AHLs as signals. This work provides the most comprehensive description of the  luxI/R  circuitry and genome-based taxonomical description of the available sphingomonad genomes to date indicating that the presence of  luxR  solos and  luxI  solos are not an uncommon feature in members of the  Sphingomonadaceae  family.

frontiers in cellular and infection microbiology

Whole genome sequencing and analysis reveal insights into the genetic structure, diversity and evolutionary relatedness of luxI and luxR homologs in bacteria belonging to the Sphingomonadaceae family