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Five new oleanane-type triterpenoid saponins ( 1–5 ), together with 24 known saponins ( 6–29 ) were isolated from the fruit of  Acanthopanax senticosus . Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds ( 1–29 ) were evaluated.

Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms