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During a screening for antifungal secondary metabolites, six new mono-/bis-alkenoic acid derivatives ( 2 – 7 ) and one known alkenoic acid derivative ( 1 ) were isolated from an endophytic fungi  Scopulariopsis candelabrum . Their chemical structures were identified by  1 H-NMR,  13 C-NMR, 2D NMR, and high-resolution mass spectrometry, as well as comparisons with previously reported literatures. Among them, fusariumesters C‒F ( 2 – 5 ) are bis-alkenoic acid derivatives dimerized by an ester bond, while acetylfusaridioic acid A ( 6 ) and fusaridioic acid D ( 7 ) are alkenoic acid monomers. All the isolates were submitted to an antifungal assay against  Candida albicans  and the corn pathogen  Exserohilum turcicum  using the filter paper agar diffusion method. As a result, only compound  1  decorating with  β -lactone ring turned out to be active against these two tested fungi. The broth microdilution assay against  Candida albicans  showed the minimum inhibitory concentration (MIC) value of  1  to be 20  μ g/ml, while the minimum inhibitory concentration value of the positive control (naystatin) was 10  μ g/ml. And the half maximal inhibitory concentration (IC 50 ) value (21.23  μ g/ml) of  1  against  Exserohilum turcicum  was determined by analyzing its inhibition effect on the mycelial growth, using cycloheximide (IC 50  = 46.70  μ g/ml) as the positive control.

Mono-/Bis-Alkenoic Acid Derivatives From an Endophytic Fungus Scopulariopsis candelabrum and Their Antifungal Activity