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Seven new clerodane diterpenoids, crassifolins Q−W ( 1 – 7 ), along with five known analogues ( 8 – 12 ), were isolated from the roots of  Croton crassifolius . Their structures were identified by comprehensive spectroscopic analysis (UV, IR, NMR, and HR-ESI-MS), and their absolute configurations were determined by ECD spectra and X-ray crystallography. The activities of compounds  1 – 5  against inflammatory cytokines IL-6 and TNF- α  levels on LPS-induced RAW 264.7 macrophages were assessed, and compound  5  showed the most significant activity with the secretion levels of IL-6 and TNF- α  at 32.78 and 12.53%, respectively. Moreover, compounds  1 – 5  were screened for their anti-angiogenesis using a human umbilical vein endothelial cells  in vitro  mode; the results showed all of them exhibited obvious anti-angiogenesis activities, in particular, compound  5  showed the strongest anti-angiogenesis effect in the range of 6.25–50 μM.

Crassifolins Q−W: Clerodane Diterpenoids From Croton crassifolius With Anti-Inflammatory and Anti-Angiogenesis Activities