English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Bacterial resistance to antibiotics has become one of the most challenging problems of infectious disease treatment. Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their  in vivo  anti-inflammatory,  in vitro  anti-microbial and anti-oxidant activities. The base promoted reactions of the appropriate amino acids with substituted benzenesulphonyl chlorides gave the benzene sulphonamides ( 3a-j ) in excellent yields. Palladium mediated amidation of the benzenesulphonamides ( 3a-j ) and butylamine gave the new carboxamides ( 4a-j ) in excellent yield. Compounds  4a  and  4c  inhibited carrageenan induced rat-paw edema at 94.69, 89.66, and 87.83% each at 1, 2, and 3 h, respectively. In the antimicrobial activity, compound  4d  (MIC 6.72 mg/mL) was most potent against  E. coli , compound  4h  (MIC 6.63 mg/mL) was the most active against  S. aureus , compound  4a  (MIC 6.67 and 6.45 mg/mL) was most active against  P. aeruginosa  and  S. typhi , respectively, compound  4f  (MIC 6.63 mg/mL) was the most active against  B. subtilis , compounds  4e  and  4h  (MIC 6.63 mg/mL) each were the most active against  C. albicans , while compound  4e  (MIC 6.28 mg/mL) was most active against  A. niger . Only compound  4e  (IC 50  0.3287 mg/mL) had comparable activity with Vitamin C (IC 50  0.2090 mg/mL).

Biological Activity Evaluation of Some New Benzenesulphonamide Derivatives