English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Seven new phenol derivatives named coleophomones E and F ( 1 ,  2 ), diorcinols L and M ( 3 ,  4 ), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone ( 5 ), porric acid E ( 6 ), and 7-(2-hydroxyphenyl) butane-7,8,9-triol ( 7 ), were isolated from the EtOAc extract of the marine sponge-derived fungus  Didymellaceae  sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of  1  and  2  contains an unusual spiro [cyclohexane-1,2′-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound  3  displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC 50  values 5.7–9.6 μM) and weak activities against other five cell lines, while  8  showed weak cytotoxicities against HeLa and HL7702 cells. Compound  6  displayed COX-2 inhibitory activity with IC 50  value of 3.3 μM.

Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp. SCSIO F46