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Background:  Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors worldwide and has poor prognosis. DEAD box proteins31 (DDX31) participate in cellular processes involving RNA secondary structure changes. However, the functions of  DDX31  in PDAC remain to be elucidated.   Methods:  The key gene  DDX31  was identified using a combination of a risk model and weighted gene co-expression network analysis (WGCNA) with R software. The biological functions of  DDX31  in PDAC were investigated through bioinformatics analysis and  in vitro  experiments.   Results:  Combining with WGCNA and risk model,  DDX31  was identified as a potential factor of the invasive metastasis properties of PDAC, and its expression was closely related to the malignant differentiation of PDAC. The results of gene set enrichment analysis (GSEA) showed that  DDX31  was correlated with cell invasive metastasis and proliferation by activating  MAPK  signaling pathway. The inhibition of  DDX31  inhibited the invasion and migration of PDAC cells. Survival analysis showed that  DDX31  expression was negatively associated with the poor prognosis in patients with PDAC.   Interpretation:  DDX31  may be a potential factor for PDAC. The inhibition of  DDX31  may be a potential way to treat PDAC.

Identification of DDX31 as a Potential Oncogene of Invasive Metastasis and Proliferation in PDAC