English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Annexin A1 (ANXA1) is a calcium-dependent phospholipid-binding protein and has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion. However, the biological role and clinical behavior of  ANXA1  in glioma remain unclear. In this study, RNA-seq ( n  = 1018 cases) and whole-exome sequencing (WES) ( n  = 286 cases) data on a Chinese cohort, RNA-seq data with different histological regions of glioblastoma blocks ( n  = 270 cases), and scRNA-seq data ( n  = 7630 cells) were used. We used the R software to perform statistical calculations and graph rendering. We found that  ANXA1  is closely related to the malignant progression in gliomas. Meanwhile,  ANXA1  is significantly associated with clinical behavior. Furthermore, the mutational profile revealed that glioma subtypes classified by  ANXA1  expression showed distinct genetic features. Functional analyses suggest that  ANXA1  correlates with the immune-related function and cancer hallmark. At a single-cell level, we found that  ANXA1  is highly expressed in M2 macrophages and tumor cells of the mesenchymal subtype. Importantly, our result suggested that  ANXA1  expression is significant with the patient’s survival outcome. Our study revealed that  ANXA1  was closely related to immune response.  ANXA1  plays a key factor in M2 macrophages and MES tumor cells. Patients with lower  ANXA1  expression levels tended to experience improved survival.  ANXA1  may become a valuable factor for the diagnosis and treatment of gliomas in clinical practice.

Molecular Characterization and Clinical Relevance of ANXA1 in Gliomas via 1,018 Chinese Cohort Patients