English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Purpose:  To systematically analyze the overall m 6 A modification pattern in hyperplastic scars (HS).   Methods:  The m 6 A modification patterns in HS and normal skin (NS) tissues were described by m 6 A sequencing and RNA sequencing, and subsequently bioinformatics analysis was performed. The m 6 A-related RNA was immunoprecipitated and verified by real-time quantitative PCR.   Results:  The appearance of 14,791 new m 6 A peaks in the HS sample was accompanied by the disappearance of 7,835 peaks. The unique m 6 A-related genes in HS were thus associated with fibrosis-related pathways. We identified the differentially expressed mRNA transcripts in HS samples with hyper-methylated or hypo-methylated m 6 A peaks.   Conclusion:  This study is the first to map the m 6 A transcriptome of human HS, which may help clarify the possible mechanism of m 6 A-mediated gene expression regulation.

The m6A RNA Modification Modulates Gene Expression and Fibrosis-Related Pathways in Hypertrophic Scar