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Meis  genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the  Meis2  gene during vertebrate inner ear induction and the formation of the cochlea.  Meis2  is expressed in several tissues required for inner ear induction and in non-sensory tissue of the cochlear duct. Global inactivation of  Meis2  in the mouse leads to a severely reduced size of the otic vesicle. Tissue-specific knock outs of  Meis2  reveal that its expression in the hindbrain is essential for otic vesicle formation. Inactivation of  Meis2  in the inner ear itself leads to an aberrant coiling of the cochlear duct. By analyzing transcriptomes obtained from  Meis2  mutants and ChIPseq analysis of an otic cell line, we define candidate target genes for  Meis2  which may be directly or indirectly involved in cochlear morphogenesis. Taken together, these data show that  Meis2  is essential for inner ear formation and provide an entry point to unveil the network underlying proper coiling of the cochlear duct.

Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea