English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Dopa decarboxylase (DDC) synthesizes serotonin in the developing mouse heart where it is encoded by  Ddc_exon1a , a tissue-specific paternally expressed imprinted gene.  Ddc_exon1a  shares an imprinting control region (ICR) with the imprinted, maternally expressed (outside of the central nervous system)  Grb10  gene on mouse chromosome 11, but little else is known about the tissue-specific imprinted expression of  Ddc_exon1a . Fluorescent immunostaining localizes DDC to the developing myocardium in the pre-natal mouse heart, in a region susceptible to abnormal development and implicated in congenital heart defects in human.  Ddc_exon1a  and  Grb10  are not co-expressed in heart nor in brain where  Grb10  is also paternally expressed, despite sharing an ICR, indicating they are mechanistically linked by their shared ICR but not by  Grb10  gene expression. Evidence from a  Ddc_exon1a  gene knockout mouse model suggests that it mediates the growth of the developing myocardium and a thinning of the myocardium is observed in a small number of mutant mice examined, with changes in gene expression detected by microarray analysis. Comparative studies in the human developing heart reveal a paternal expression bias with polymorphic imprinting patterns between individual human hearts at  DDC_EXON1a , a finding consistent with other imprinted genes in human.

Imprinted Gene Expression and Function of the Dopa Decarboxylase Gene in the Developing Heart