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Toxoplasmosis is a global zoonotic disease, and one-third of the human population is chronically infected by  Toxoplasma gondii . Due to the limited effectiveness and prominent side effects of the existing drugs, there is a dire need for the discovery of new therapeutic options in the treatment of toxoplasmosis. In this study, five essential oils (EO) were screened for their anti-parasitic activity against  T. gondii . The cytotoxicity of essential oils was evaluated using the MTT assay on human foreskin fibroblast cells. The CC 50  values of  Eucalyptus globulus  EO,  Cupressus sempervirens  EO,  Citrus aurantifolia  EO,  Melaleuca alternifolia  EO, and  Pelargonium X. asperum (Pa)  EO were found to be 22.74, 7.25, 15.01, 6.26, and 4.77 mg/mL, respectively. Only  Pa EO exhibited anti-parasitic activity, and inhibited the growth of  T. gondii  in a dose-dependent manner. In addition, treatment with  Pa EO, was found to reduce the volume of  T. gondii  tachyzoites and make their membrane surfaces rough. These results showed that  Pa EO was able to inhibit the growth of  T. gondii  by reducing invasion, which may be due to its detrimental effect on the ability of tachyzoites to move. These findings suggest that  Pa EO could be a potential anti- T. gondii  drug, which may facilitate the development of new and effective treatments against toxoplasmosis.

In vitro Anti-parasitic Activity of Pelargonium X. asperum Essential Oil Against Toxoplasma gondii