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Boron oxide nanoparticles (nB 2 O 3 ) are manufactured for structural, propellant, and clinical applications and also form spontaneously through the degradation of bulk boron compounds. Bulk boron is not toxic to vertebrates but the distinctive properties of its nanostructured equivalent may alter its biocompatibility. Few studies have addressed this possibility, thus our goal was to gain an initial understanding of the potential acute toxicity of nB 2 O 3  to freshwater fish and we used a variety of model systems to achieve this. Bioactivity was investigated in rainbow trout ( Oncorhynchus mykiss ) hepatocytes and at the whole animal level in three other North and South American fish species using indicators of aerobic metabolism, behavior, oxidative stress, neurotoxicity, and ionoregulation. nB 2 O 3  reduced  O. mykiss  hepatocyte oxygen consumption ( Ṁ O 2 ) by 35% at high doses but whole animal  Ṁ O 2  was not affected in any species. Spontaneous activity was assessed using  Ṁ O 2  frequency distribution plots from live fish. nB 2 O 3  increased the frequency of high  Ṁ O 2  events in the Amazonian fish  Paracheirodon axelrodi , suggesting exposure enhanced spontaneous aerobic activity.  Ṁ O 2  frequency distributions were not affected in the other species examined. Liver lactate accumulation and significant changes in cardiac acetylcholinesterase and gill Na + /K + -ATPase activity were noted in the north-temperate  Fundulus diaphanus  exposed to nB 2 O 3 , but not in the Amazonian  Apistogramma agassizii  or  P. axelrodi . nB 2 O 3  did not induce oxidative stress in any of the species studied. Overall, nB 2 O 3  exhibited modest, species-specific bioactivity but only at doses exceeding predicted environmental relevance. Chronic, low dose exposure studies are required for confirmation, but our data suggest that, like bulk boron, nB 2 O 3  is relatively non-toxic to aquatic vertebrates and thus represents a promising formulation for further development.

Boron Oxide Nanoparticles Exhibit Minor, Species-Specific Acute Toxicity to North-Temperate and Amazonian Freshwater Fishes