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Background  While  in vitro  wear simulation of unicompartmental knee arthroplasty (UKA) showed outstanding long-term wear performance, studies reported that polyethylene (PE) wear was responsible for 12% fixed-bearing (FB) UKA failure. This paper aimed to quantify the  in vivo  6-degrees-of-freedom (6-DOF) knee kinematics and contact positions of FB UKA during daily activities and compare with the previous results of  in vitro  wear simulator.    Methods  Fourteen patients following unilateral medial FB UKA received a CT scan and dual fluoroscopic imaging during level walking, single-leg deep lunge, and sit-to-stand motion for evaluating  in vivo  6-DOF FB UKA kinematics. The closest point between surface models of the femoral condyle and PE insert was determined to locate the medial compartmental articular contact positions, which were normalized relative to the PE insert length. The  in vivo  contact area was compared with the  in vitro  wear region in previous simulator studies.    Results  The  in vivo  contact positions during daily activities were more anterior than those in the previous  in vitro  wear simulator studies ( p  < 0.001). Significant differences in the femoral anteroposterior translation and tibial internal rotation during the stance phase were observed and compared with those in lunge and sit-to-stand motions ( p  < 0.05). The  in vivo  contact position located anteriorly and medially by 5.2 ± 2.7 and 1.8 ± 1.6 mm on average for the stance phase, 1.0 ± 2.4 and 0.9 ± 1.5 mm for the lunge, and 2.1 ± 3.3 and 1.4 ± 1.4 mm for sit-to-stand motion. The  in vivo  contact position was in the more anterior part during the stance phase ( p  < 0.05).    Conclusion  The current study revealed that the contact position of FB UKA was located anteriorly and medially on the PE insert during  in vivo  weight-bearing activities and different from previous findings of the  in vitro  wear simulator. We should take  in vivo  6-DOF knee kinematics and contact patterns of FB UKA into account to reproduce realistic wear performance for  in vitro  wear simulator and to improve implant design.

frontiers in bioengineering and biotechnology

More Anterior in vivo Contact Position in Patients With Fixed-Bearing Unicompartmental Knee Arthroplasty During Daily Activities Than in vitro Wear Simulator