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A variational problem for a fourth order parabolic surface partial differential equation is discussed. It contains non-linear lower order terms, on which we only make abstract assumptions, and which need to be defined for specified problems. We derive a semi-discrete scheme based on the surface finite element method, show a-priori error estimates, and use the analytical results to prove well-posedness. Furthermore, we present a computational framework where specific problems can be conveniently implemented and, later on, altered with relative ease. It uses a domain specific language implemented in Python. The high level program control can also be done within the Python scripting environment. The computationally expensive step of evolving the solution over time is carried out by binding to an efficient C++ software back-end. The study is motivated by cell blebbing, which can be instrumental for cell migration. Starting with a force balance for the cell membrane, we derive a continuum model for some mechanical and geometrical aspects of the onset of blebbing in a form that fits into the abstract framework. It is flexible in that it allows for amending force contributions related to membrane tension or the presence of linker molecules between membrane and cell cortex. Cell membrane geometries given in terms of a parameterization or obtained from image data can be accounted for by the software. The use of a domain specific language to describe the model makes is straightforward to add additional effects such as reaction-diffusion equations modeling some biochemistry on the cell membrane. Some numerical simulations illustrate the approach.

A Finite Element Method for a Fourth Order Surface Equation With Application to the Onset of Cell Blebbing