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The effects of prenatal alkaloidic extract of tobacco plant exposure on behavioral parameters in sprague-dawley rat offspring were assessed. Pregnant rats were exposed by oral away of Alkaloid of tobacco plant on all gestational period. Controls received the physiological water. Before weaning, the offspring were examined using the cliff avoidance response (6 days of age), the negative geotaxis reflex (7 days), and swimming development (10 and 12 days). The preweaning offspring in the traited group showed significantly lower success rates than controls in cliff avoidance responses and in negative geotaxis reflex. In swimming development, the offspring in the traited group had significantly lower scores than controls for swimming direction. These results indicate that prenatal exposure to alkaloidic extract of tobacco plant produced a delay of early response development in the offspring of rats exposed to akaloidic extract of tobacco plant during all pregnancy.

Effect of melanopsin deletion on the expression of the Per2 gene in the mouse retina