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Methods: Ten healthy subjects (7 females, mean age 24±3years) underwent high density EEG recordings in both eye close awake resting state and hypnosis state. The hypnotic state instruction involved a 3-min induction procedure with muscle relaxation and eye fixation. After preprocessing EEG data, both hypothesis and data driven analysis were conducted using connectivity approach. Classical power spectral analysis was performed for delta (1-4Hz), theta (4.1-8Hz), alpha (8.1-12Hz), beta1 (12.1-20Hz) and beta2 (20.1-30Hz) frequency bands. Connectivity between every pair of electrodes was assessed using weighted Phase Lag Index. Hypothesis-based connectivity was computed for frontal, parietal and midline regions [2]. Data-driven graph theory connectivity was carried out to measure brain connectivity network properties and altered hub regions [3].

Neural correlates of modified subjective state of consciousness induced by hypnosis using EEG-connectivity approach