English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aim Repetitive transcranial magnetic stimulation may have anti-epileptic effects, especially in neocortical epilepsy. Continuous thetaburst stimulation (cTBS) seems to be a potent protocol that could optimize safety, tolerability and applicability based on lower stimulation intensity and shorter duration. Methods Patients with refractory neocortical epilepsy are treated with a 4-day cTBS protocol (figure 1) targeted over the epileptogenic focus. Seizure frequency and adverse events are assessed over a 4-week baseline period and 8 weeks of follow-up. Cognitive and psychological testing is performed at baseline and end of follow-up. Results Subject 1 and subject 2 suffer from epilepsy due to a low-grade tumor in the motor cortex causing focal clonic seizures. Subject 1 also experiences myoclonia of the left leg. Subject 3 has epilepsy with auditory seizures following intracranial hemorrhage in the left temporal lobe. cTBS was well-tolerated and did not induce serious adverse events or seizures. Mild headache occurred in subject 3. No negative cognitive or psychological side effects were noticed. Anti-epileptic effects of cTBS varied (figure 2). Subject 1 experienced a transient reduction in severity of clonic seizures, with complete resolution of myoclonia for 6 weeks. Subject 2 experienced an overall 50% seizure frequency reduction, with most pronounced effect during treatment and initial 4 weeks of follow-up (70% reduction, 3 seizure-free weeks). No marked effect on seizures was identified in subject 3. Conclusions cTBS appears safe and well-tolerated, even in seizure-prone subjects. Anti-epileptic effects of variable extent were identified. Extensive parenchymal damage at the target site may have interfered with effective stimulation in subject 3.

Continuous thetaburst stimulation for the treatment of refractory neocortical epilepsy