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Hyperuricemia that causes arthritis requires treatment management using natural ingredients. The purpose of this study was to examine the activity of a typical Lombok herb RAJALOM on uric acid levels in plasma and urine and to influence the histopathological features of the aorta in Rattus novergicus experimental animals with hyperuricema induced by a diet high in cholesterol and purines. This study used experimental animals Rattus norvegicus induced by a diet high in purine and choleterol combined with potassium oxanate IP 42 mg / 200 kkBW rats. White rats were divided into 8 groups. Hyperurecemic white rats were treated with distilled water per sonde for the negatif control group, allopurinol 1.8 mg/200gram BW Rats for the positive control group and the treatment group given a typical Lombok herb RAJALOM. At the end of the treatment, samples of blood, urine and aorta were taken for examination of plasma uric acid levels, uric acid levels and aortic histopathology. The results of this study were that giving herbs from Lombok RAJALOM for 7 and 14 days was able to reduce uric acid levels in experimental animals with a range between and 45.7% 77.27%, while in the positive control group / Allopurinol was able to reduce up to 86% on the day. 14. There was no significant relationship between the treatment groups on plasma uric acid levels of experimental animals on day 7 and day 14. There was no significant difference between uric acid levels before treatment and according to treatment in all study groups. The induction of high fat / purine feed for 3 weeks in experimental mice (Rattus Novergicus) did not cause the formation of atherosclerotic plaques. The conclusion is that giving herbs from Lombok RAJALOM for 7 and 14 days was able to reduce uric acid levels in animal plasma.

Sediaan “RAJALOM” (Ramuan Jamu Lombok) terhadap Kadar Asam Urat Plasma dan Gambaran Histopatologi Aorta Rattus novergicus